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ABSTRACT QUESTION If a mother takes a sedating drug during breastfeeding, will it cause central nervous system (CNS) depression in her breastfed baby?ANSWER In some cases (eg, with the use of codeine or oxycodone) sedating drugs will likely cause CNS depression in breastfed infants and in other cases (eg, with the use of benzodiazepines) they will likely not. Agents where the main therapeutic effect is mediated by negative modulation of histamine receptors are termed antihistamines; other agents may have antihistaminergic action but are not true antihistamines.In common use, the term "antihistamine" refers only to H In type I hypersensitivity allergic reactions, an allergen (a type of antigen) interacts with and cross-links surface Ig E antibodies on mast cells and basophils.Piperazine derivatives include cetirizine, cyclizine, and hydroxyzine.Cetirizine causes less sedation than other members of this group.

QUESTION Les sédatifs qu'une mère prend pendant qu'elle allaite pourraient-ils causer une dépression du système nerveux central (SNC) chez son enfant allaité? Les mères qui prennent des sédatifs devraient surveiller chez leur enfant allaité des signes de dépression du SNC (p. somnolence, difficulté à respirer, à s'alimenter ou à prendre le sein, ou encore cyanose), des réactions paradoxales (p. excitation inhabituelle, irritabilité) ou un gain de poids insuffisant.Benzodiazepines (BZDs), antihistamines, and opioids are a few classes of sedating drugs commonly used by breastfeeding mothers.As a general rule, when the relative infant dose (the amount of a drug excreted into breast milk relative to the maternal dose) is less than 10%, it is considered compatible with breastfeeding.Brompheniramine and chlorpheniramine are typical alkylamine antihistamines. They cause moderate sedation (despite having weak CNS effects), gastric disturbances, and skin sensitization.Antazoline, mepyramine and tripelennamine are examples. this group of antihistamines possesses moderate sedative and significant antiemetic actions.Clinically useful H1-antihistamines such as phenbenzamine, pyrilamine, and diphenhydramine were introduced in the 1940s.

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